1701 Grant Ave, Philadelphia, PA 19115, USA
Tel: 215-464-3838
SPRAVATO® is the first nasal spray medication specifically for adults with treatment-resistant depression
Nasal spray you self-administer under the supervision of a healthcare professional

Studied in adults with treatment-resistant depression and taken with a daily oral antidepressant
In clinical trials, after 16 weeks of therapy, patients who stayed on SPRAVATO® were less likely to experience a return of depressive symptoms than those who stopped therapy
Greater reduction of depressive symptoms at four weeks (compared to those who received a placebo and oral antidepressant)
After you take SPRAVATO®, a healthcare provider will monitor you for at least two hours during the observation period for possible serious side effects
FAQ
Most frequent questions and answers
Please call your insurance company and ask if treatment with Spravato (esketamine) is covered. The manufacturer of Spravato (Janssen) also provides assistance for patients in determining insurance coverage and may also be able to provide some financial support for your treatment. Please call the Janssen CarePath Program at 844-777-2828
WHAT SHOULD I DO FIRST IF I AM INTERESTED IN THIS TREATMENT OPTION?
If you are covered then please call our practice at (215) 464-3838 to make an appointment. Our office will schedule you for an evaluation with Dr. Salzberg as soon as possible to assess your case and determine whether Spravato (esketamine) is the next best treatment for your case of TRD. We will also discuss what other treatment options should be considered for you in that regard.
WHAT IS THE NEXT STEP IF I HAVE INSURANCE COVERAGE FOR SPRAVATO?
WHAT IS THE NEXT STEP AFTER MY EVALUATION?
Your first treatment session for administration of the intranasal treatment with Spravato will be scheduled promptly if Spravato (esketamine) is the right treatment for you.
WHAT HAPPENS AT THE OFFICE DURING MY VISITS FOR SPRAVATO (ESKETAMINE) TREATMENT?
Each visit to the office for treatment will take about two and a half hours. First your dose of Spravato is administered in the doctor’s office. Next there is a 2 hour safety monitoring period. During this time your blood pressure will be monitored. You will also be checked for any sedation and presence of any dissociative symptoms (feeling strange, disconnected transiently) or any other side effects. After 2 hours, if you are stable then you will then be discharged home. You will need somebody to drive you home after the treatment.
WHAT ARE THE COMMON SIDE EFFECTS WITH SPRAVATO (ESKETAMINE?)
These include transient sedation, a possible rise in your blood pressure and feelings of dissociation (such feeling strange, disconnected or change in sense of time). These side effects may typically be present for the first 2 hours after taking the nasal spray of ketamine. For this reason you are monitored in the doctor’s office for a period of 2 hours after your dose of Spravato (esketamine). Such side effects if they occur typically go away the same day. During this time your blood pressure will be checked periodically and you will be assessed for the presence of any specific side effects. After 2 hours the doctor will assess you clinically to make sure you are safe to be discharged home.
HOW OFTEN ARE THE TREATMENTS?
For the first 4 weeks you come in twice per week, each time for a two and a half hour visit. In the second month your visits are now once per week. After that treatments for long term maintenance with Spravato (esketamine) might be once per week or twice per month depending on your clinical course.
HOW IS PAYMENT FOR THIS TREATMENT HANDLED AT THIS PRACTICE?
We will work with your insurance company to cover this service
WHAT IS THE COST OF THE TREATMENT?
We accept most insurances and will try to get it authorized. Some or all of the following charges may be covered by your insurance. The initial evaluation for 70 minutes is $300. Each visit for Spravato (esketamine) treatment administration (2.5hrs) costs $400 if not covered by insurance. Payment is due at the time of service.
CAN I TAKE SPRAVATO (ESKETAMINE) AT HOME?
This is prohibited by the FDA as ketamine has the potential to be abused and therefore lead to addiction. Therefore, administration is solely at the doctor’s office.
